Benzoic acid, 3-amino-5-(trifluoromethyl)- - Names and Identifiers
Benzoic acid, 3-amino-5-(trifluoromethyl)- - Physico-chemical Properties
Molecular Formula | C8H6F3NO2
|
Molar Mass | 205.13 |
Density | 1.489±0.06 g/cm3(Predicted) |
Melting Point | 141-146°C(lit.) |
Boling Point | 331.9±42.0 °C(Predicted) |
Appearance | powder to crystal |
Color | Light yellow to Yellow to Orange |
pKa | 3.93±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
MDL | MFCD00236641 |
Benzoic acid, 3-amino-5-(trifluoromethyl)- - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | DD6205700 |
Hazard Class | IRRITANT |
Benzoic acid, 3-amino-5-(trifluoromethyl)- - Introduction
3-Amino-5-(trifluoromethyl)benzoic acid is an organic compound with the chemical formula C8H6F3NO2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White to pale yellow crystalline solid.
-Solubility: Soluble in acidic and alkaline solutions, slightly soluble in ethanol and ether, almost insoluble in water.
-Melting point: about 165-168 ℃.
-Stability: Stable at room temperature, but will decompose under high temperature or light conditions.
Use:
-Chemical reagents: As intermediates and reagents in organic synthesis, they are commonly used in the synthesis of organic compounds such as drugs and pesticides.
-Enzyme inhibitor: It has the property of inhibiting the activity of some enzymes and can be used in biological research.
-Pigments: can be used as raw materials for dyes and pigments.
Method:
The preparation method of 3-Amino-5-(trifluoromethyl)benzoic acid includes the following steps:
1. Cyclopentene is reacted with hexafluoroethanone to give 3,4, 5-trifluorocyclopentanone.
2.3,4,5-trifluorocyclopentanone reacts with Aminobenzoic acid and rearranges under alkaline conditions to generate 3-Amino-5-(trifluoromethyl)benzoic acid.
Safety Information:
-The compound is irritating and avoid direct contact with skin and eyes.
-It is recommended to wear appropriate protective equipment such as gloves, goggles and lab coats during operation.
-Avoid contact with oxidant, fire and heat sources during storage.
-If taken by mistake or inhaled, seek medical help immediately.
-When performing experiments or operations, follow relevant safety procedures and personal protective measures.
Last Update:2024-04-09 15:17:56